Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells

Sirtuin-1 (SIRT1), NAD(+)-dependent deacetylase, has been linked to anabolic effects in cartilage, although the mechanisms of SIRT1 signaling during differentiation of mesenchymal stem cells (MSCs) to chondrocytes are poorly understood. Therefore, we investigated the role of SIRT1-mediated signaling...

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Bibliografiske detaljer
Main Authors: Buhrmann, Constanze, Busch, Franziska, Shayan, Parviz, Shakibaei, Mehdi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139220/
https://ncbi.nlm.nih.gov/pubmed/24962570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568790
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