Resveratrol Mediated Modulation of Sirt-1/Runx2 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells: Potential Role of Runx2 Deacetylation

OBJECTIVE: Osteogenic repair in response to bone injury is characterized by activation and differentiation of mesenchymal stem cells (MSCs) to osteoblasts. This study determined whether activation of Sirt-1 (a NAD(+)-dependent histone deacetylase) by the phytoestrogen resveratrol affects osteogenic...

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Detalhes bibliográficos
Main Authors: Shakibaei, Mehdi, Shayan, Parviz, Busch, Franziska, Aldinger, Constance, Buhrmann, Constanze, Lueders, Cora, Mobasheri, Ali
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335081/
https://ncbi.nlm.nih.gov/pubmed/22539994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035712
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