Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS

Domoic acid is an algal-derived seafood toxin that functions as a glutamate agonist and exerts excitotoxicity via overstimulation of glutamate receptors (AMPA, NMDA) in the central nervous system (CNS). At high (symptomatic) doses, domoic acid is well-known to cause seizures, brain lesions and memor...

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Detalhes bibliográficos
Main Authors: Hiolski, Emma M, Kendrick, Preston S, Frame, Elizabeth R, Myers, Mark S, Bammler, Theo K, Beyer, Richard P, Farin, Federico M, Wilkerson, Hui-wen, Smith, Donald R, Marcinek, David J, Lefebvre, Kathi A
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139102/
https://ncbi.nlm.nih.gov/pubmed/25033243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aquatox.2014.06.006
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