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Asteropsins B–D, sponge-derived knottins with potential utility as a novel scaffold for oral peptide drugs
BACKGROUND: Known linear knottins are unsuitable as scaffolds for oral peptide drug due to their gastrointestinal instability. Herein, a new subclass of knottin peptides from Porifera is structurally described and characterized regarding their potential for oral peptide drug development. METHODS: As...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139099/ https://ncbi.nlm.nih.gov/pubmed/24225326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.11.001 |
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