CLEC‐2‐dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP

BACKGROUND: The activation of platelet CLEC‐2 by podoplanin on lymphatic endothelial cells (LECs) has a critical role in prevention of mixing of lymphatic and blood vasculatures during embryonic development. Paradoxically, LECs release cAMP and cGMP‐elevating agents, prostacyclin (PGI(2)) and nitric...

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Main Authors: Borgognone, A., Navarro‐Núñez, L., Correia, J. N., Pollitt, A. Y., Thomas, S. G., Eble, J. A., Pulcinelli, F. M., Madhani, M., Watson, S. P.
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Pub 2014
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138994/
https://ncbi.nlm.nih.gov/pubmed/24460629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12514
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