Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

Dynamin GTPase activity increases when it oligomerizes either into helices in the presence of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a dynamin inhibitor of moderate potency (IC(50) ˜ 15 μM in vitro). We show that dynasore binds stoichiometrically to deterge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McCluskey, Adam, Daniel, James A., Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L., Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N., Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B., Howes, Mark T., Parton, Robert G., Campbell, Michael, Sakoff, Jennette A., Wang, Xuefeng, Sun, Jian‐Yuan, Robertson, Mark J., Deane, Fiona M., Nguyen, Tam H., Meunier, Frederic A., Cousin, Michael A., Robinson, Phillip J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley & Sons A/S 2013
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138991/
https://ncbi.nlm.nih.gov/pubmed/24025110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12119
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