Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

Dynamin GTPase activity increases when it oligomerizes either into helices in the presence of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a dynamin inhibitor of moderate potency (IC(50) ˜ 15 μM in vitro). We show that dynasore binds stoichiometrically to deterge...

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Detalhes bibliográficos
Main Authors: McCluskey, Adam, Daniel, James A., Hadzic, Gordana, Chau, Ngoc, Clayton, Emma L., Mariana, Anna, Whiting, Ainslie, Gorgani, Nick N., Lloyd, Jonathan, Quan, Annie, Moshkanbaryans, Lia, Krishnan, Sai, Perera, Swetha, Chircop, Megan, von Kleist, Lisa, McGeachie, Andrew B., Howes, Mark T., Parton, Robert G., Campbell, Michael, Sakoff, Jennette A., Wang, Xuefeng, Sun, Jian‐Yuan, Robertson, Mark J., Deane, Fiona M., Nguyen, Tam H., Meunier, Frederic A., Cousin, Michael A., Robinson, Phillip J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons A/S 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138991/
https://ncbi.nlm.nih.gov/pubmed/24025110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12119
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