Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate**

Mannosidases catalyze the hydrolysis of a diverse range of polysaccharides and glycoconjugates, and the various sequence-based mannosidase families have evolved ingenious strategies to overcome the stereoelectronic challenges of mannoside chemistry. Using a combination of computational chemistry, in...

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Detalhes bibliográficos
Main Authors: Williams, Rohan J, Iglesias-Fernández, Javier, Stepper, Judith, Jackson, Adam, Thompson, Andrew J, Lowe, Elisabeth C, White, Jonathan M, Gilbert, Harry J, Rovira, Carme, Davies, Gideon J, Williams, Spencer J
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2014
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138987/
https://ncbi.nlm.nih.gov/pubmed/24339341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201308334
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