Differentially Regulated Protein Kinase A (PKA) Activity in Adipose Tissue and Liver Is Associated With Resistance to Diet-Induced Obesity and Glucose Intolerance in Mice That Lack PKA Regulatory Subunit Type IIα

The cAMP-dependent protein kinase A (PKA) signaling system is widely expressed and has a central role in regulating cellular metabolism in all organ systems affected by obesity. PKA has four regulatory (RIα, RIIα, RIβ, RIIβ) and four catalytic (Cα, Cβ, Cγ, Prkx) subunit isoforms that have tissue-spe...

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Hlavní autoři: London, Edra, Nesterova, Maria, Sinaii, Ninet, Szarek, Eva, Chanturiya, Tatyana, Mastroyannis, Spyridon A., Gavrilova, Oksana, Stratakis, Constantine A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2014
Témata:
Energy Balance-Obesity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138573/
https://ncbi.nlm.nih.gov/pubmed/24914943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1122
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