Activation of TRPML1 Clears Intraneuronal Aβ in Preclinical Models of HIV Infection

Antiretroviral therapy extends the lifespan of human immunodeficiency virus (HIV)-infected patients, but many survivors develop premature impairments in cognition. These residual cognitive impairments may involve aberrant deposition of amyloid β-peptides (Aβ). By unknown mechanisms, Aβ accumulates i...

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Detalhes bibliográficos
Main Authors: Bae, Mihyun, Patel, Neha, Xu, Haoxing, Lee, Mingwaoh, Tominaga-Yamanaka, Kumiko, Nath, Avindra, Geiger, Jonathan, Gorospe, Myriam, Mattson, Mark P., Haughey, Norman J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138351/
https://ncbi.nlm.nih.gov/pubmed/25143627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0210-14.2014
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