Pivotal Role of MUC1 Glycosylation by Cigarette Smoke in Modulating Disruption of Airway Adherens Junctions In Vitro

Cigarette smoke increases the risk of lung cancer by 20-fold and accounts for 87% of lung cancer deaths. In the normal airway, heavily O-glycosylated mucin-1 (MUC1) and adherens junctions (AJs) establish a structural barrier that protects the airway from infectious, inflammatory and noxious stimuli....

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Main Authors: Zhang, Lili, Gallup, Marianne, Zlock, Lorna, Chen, Yu Ting Feeling, Finkbeiner, Walter E., McNamara, Nancy A.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138268/
https://ncbi.nlm.nih.gov/pubmed/24838315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4375
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