Cigarette Smoke Induces Epidermal Growth Factor Receptor-Dependent Redistribution of Apical MUC1 and Junctional β-Catenin in Polarized Human Airway Epithelial Cells

Cigarette smoke (CS) accounts for nearly 90% of lung cancer deaths worldwide; however, an incomplete understanding of how CS initiates preneoplastic changes in the normal airway hinders early diagnosis. Short-term exposure to CS causes aberrant activation of epidermal growth factor receptor (EGFR) a...

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Hlavní autoři: Chen, Ying-Ting, Gallup, Marianne, Nikulina, Karina, Lazarev, Stanislav, Zlock, Lorna, Finkbeiner, Walter, McNamara, Nancy
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928959/
https://ncbi.nlm.nih.gov/pubmed/20651243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091129
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