Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1

Triple negative breast cancer (TNBC) is known to contain a high percentage of CD44(+)/CD24(−/low) cancer stem cells (CSC), corresponding with a poor prognosis despite systemic chemotherapy. Chloroquine (CQ), an anti-malarial drug, is a lysotropic reagent which inhibits autophagy. CQ was identified a...

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Detalhes bibliográficos
Main Authors: Choi, Dong Soon, Blanco, Elvin, Kim, Yoo-Shin, Rodriguez, Angel A., Zhao, Hong, Huang, Tim Hui-Ming, Chen, Chun-Liang, Jin, Guangxu, Landis, Melissa D., Burey, Lacey A., Qian, Wei, Granados, Sergio M., Dave, Bhuvanesh, Wong, Helen H., Ferrari, Mauro, Wong, Stephen TC, Chang, Jenny C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138251/
https://ncbi.nlm.nih.gov/pubmed/24809620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1746
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