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Inflammation programs self-reactive CD8(+) T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance
CD8(+) T cells must detect foreign antigens and differentiate into effector cells to eliminate infections. But, when self-antigen is recognized instead, mechanisms of peripheral tolerance prevent acquisition of effector function to avoid autoimmunity. These distinct responses are influenced by infla...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Leukocyte Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4138202/ https://ncbi.nlm.nih.gov/pubmed/24823810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1A0913-500RR |
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