The Flavones Apigenin and Luteolin Induce FOXO1 Translocation but Inhibit Gluconeogenic and Lipogenic Gene Expression in Human Cells

The flavones apigenin (4′,5,7,-trihydroxyflavone) and luteolin (3′,4′,5,7,-tetrahydroxyflavone) are plant secondary metabolites with antioxidant, antiinflammatory, and anticancer activities. We evaluated their impact on cell signaling pathways related to insulin-resistance and type 2 diabetes. Apige...

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Main Authors: Bumke-Vogt, Christiane, Osterhoff, Martin A., Borchert, Andrea, Guzman-Perez, Valentina, Sarem, Zeinab, Birkenfeld, Andreas L., Bähr, Volker, Pfeiffer, Andreas F. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4138109/
https://ncbi.nlm.nih.gov/pubmed/25136826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104321
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