CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization in a murine breast cancer model

Tumor associated macrophages play a vital role in determining the outcome of breast cancer. We investigated the contribution of the chemokine receptor CXCR3 to antitumor immune responses using a cxcr3 deficient mouse orthotopically injected with a PyMT breast cancer cell line. We observed that cxcr3...

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Main Authors: Oghumu, Steve, Varikuti, Sanjay, Terrazas, Cesar, Kotov, Dmitri, Nasser, Mohd W, Powell, Catherine A, Ganju, Ramesh K, Satoskar, Abhay R
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137960/
https://ncbi.nlm.nih.gov/pubmed/24679047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12293
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