Urinary coproporphyrin I/(I + III) ratio as a surrogate for MRP2 or other transporter activities involved in methotrexate clearance

AIMS: The urinary coproporphyrin I/(I + III) ratio may be a surrogate for MRP2 activity. We conducted a prospective study in patients receiving methotrexate (MTX) to examine the relationship between this ratio and the pharmacokinetics of a MRP2 substrate. METHODS: Three urine samples were collected...

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Hlavní autoři: Benz-de Bretagne, Isabelle, Zahr, Noël, Le Gouge, Amélie, Hulot, Jean-Sébastien, Houillier, Caroline, Hoang-Xuan, Khe, Gyan, Emmanuel, Lissandre, Séverine, Choquet, Sylvain, Le Guellec, Chantal
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2014
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137825/
https://ncbi.nlm.nih.gov/pubmed/24433481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12326
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