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Improved Variant Calling Accuracy by Merging Replicates in Whole-Exome Sequencing Studies

In large scale population-based whole-exome sequencing (WES) studies, there are some samples occasionally sequenced two or more times due to a variety of reasons. To investigate how to efficiently utilize these duplicated sequencing data, we conducted comprehensive evaluation of variant calling stra...

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Detalhes bibliográficos
Main Authors: Zhang, Yanfeng, Li, Bingshan, Li, Chun, Cai, Qiuyin, Zheng, Wei, Long, Jirong
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137624/
https://ncbi.nlm.nih.gov/pubmed/25162009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/319534
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