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Performance assessment of variant calling pipelines using human whole exome sequencing and simulated data

BACKGROUND: Whole exome sequencing (WES) is a cost-effective method that identifies clinical variants but it demands accurate variant caller tools. Currently available tools have variable accuracy in predicting specific clinical variants. But it may be possible to find the best combination of aligne...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Kumaran, Manojkumar, Subramanian, Umadevi, Devarajan, Bharanidharan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580603/
https://ncbi.nlm.nih.gov/pubmed/31208315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-2928-9
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