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Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor

[Image: see text] On the basis of the three-dimensional diversity-oriented conformational restriction strategy using key chiral cyclopropane units, we previously identified 3 ((2S,3R)-4-amino-3,4-methanobutyric acid) with a chiral trans-cyclopropane structure as a γ-aminobutyric acid (GABA) transpor...

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Detalhes bibliográficos
Main Authors: Kobayashi, Takaaki, Suemasa, Akihiro, Igawa, Arisa, Ide, Soichiro, Fukuda, Hayato, Abe, Hiroshi, Arisawa, Mitsuhiro, Minami, Masabumi, Shuto, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137383/
https://ncbi.nlm.nih.gov/pubmed/25147609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500134k
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