TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

We describe transgenic mice carrying germline variable gene segments associated with either the T cell receptor (TCR) beta or alpha gene enhancers (E beta or E alpha). Transgenic constructs underwent high rates of site-specific rearrangements predominantly in T cells from independent mice. Rearrange...

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Main Authors: Capone, M, Watrin, F, Fernex, C, Horvat, B, Krippl, B, Wu, L, Scollay, R, Ferrier, P
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC413730/
https://ncbi.nlm.nih.gov/pubmed/8223443
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