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Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins

Stabilization of protein tertiary structure by disulfides can interfere with glycosylation of acceptor sites (NXT/S) in nascent polypeptides. Here, we show that MagT1, an ER-localized thioredoxin homologue, is a subunit of the STT3B isoform of the oligosaccharyltransferase (OST). The lumenally orien...

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Bibliografiske detaljer
Main Authors: Cherepanova, Natalia A., Shrimal, Shiteshu, Gilmore, Reid
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137057/
https://ncbi.nlm.nih.gov/pubmed/25135935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404083
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