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Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins
Stabilization of protein tertiary structure by disulfides can interfere with glycosylation of acceptor sites (NXT/S) in nascent polypeptides. Here, we show that MagT1, an ER-localized thioredoxin homologue, is a subunit of the STT3B isoform of the oligosaccharyltransferase (OST). The lumenally orien...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137057/ https://ncbi.nlm.nih.gov/pubmed/25135935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404083 |
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