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The nebulin repeat protein Lasp regulates I-band architecture and filament spacing in myofibrils
Mutations in nebulin, a giant muscle protein with 185 actin-binding nebulin repeats, are the major cause of nemaline myopathy in humans. Nebulin sets actin thin filament length in sarcomeres, potentially by stabilizing thin filaments in the I-band, where nebulin and thin filaments coalign. However,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137052/ https://ncbi.nlm.nih.gov/pubmed/25113030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201401094 |
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