JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma

BACKGROUND: As a commonly mutated form of the epidermal growth factor receptor, EGFRvIII strongly promotes glioblastoma (GBM) tumor invasion and progression, but the mechanisms underlying this promotion are not fully understood. METHODS: Through gene manipulation, we established EGFRvIII-, wild-type...

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Bibliographische Detailangaben
Hauptverfasser: Zheng, Qifan, Han, Lei, Dong, Yucui, Tian, Jing, Huang, Wei, Liu, Zhaoyu, Jia, Xiuzhi, Jiang, Tao, Zhang, Jianning, Li, Xia, Kang, Chunsheng, Ren, Huan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136898/
https://ncbi.nlm.nih.gov/pubmed/24861878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou046
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