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HEDGEHOG-GLI signaling inhibition suppresses tumor growth in squamous lung cancer

PURPOSE: Lung squamous cell carcinoma (LSCC) currently lacks effective targeted therapies. Previous studies reported overexpression of HEDGEHOG (HH)-GLI signaling components in LSCC. However, they addressed neither the tumor heterogeneity nor the requirement for HH-GLI signaling. Here, we investigat...

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Detalhes bibliográficos
Main Authors: Huang, Lingling, Walter, Vonn, Hayes, D. Neil, Onaitis, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136748/
https://ncbi.nlm.nih.gov/pubmed/24423612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2195
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