Computational Protein Design to Re-Engineer Stromal Cell-Derived Factor-1α (SDF) Generates an Effective and Translatable Angiogenic Polypeptide Analog

BACKGROUND: After ischemic injury, cardiac secretion of the potent endothelial progenitor stem cell (EPC) chemokine SDF stimulates endogenous neovascularization and myocardial repair, a process insufficiently robust to repair major infarcts. Experimentally, exogenous administration of recombinant SD...

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Detalhes bibliográficos
Main Authors: Hiesinger, William, Perez-Aguilar, Jose Manuel, Atluri, Pavan, Marotta, Nicole A., Frederick, John R., Fitzpatrick, J. Raymond, McCormick, Ryan C., Muenzer, Jeffrey R., Yang, Elaine C., Levit, Rebecca D., Yuan, Li-Jun, MacArthur, John W., Saven, Jeffery G., Woo, Y. Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136555/
https://ncbi.nlm.nih.gov/pubmed/21911811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.009431
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