Period 2 Mutation Accelerates Apc(Min/+) Tumorigenesis

Colorectal cancer risk is increased in shift workers with presumed circadian disruption. Intestinal epithelial cell proliferation is gated throughout each day by the circadian clock. Period 2 (Per2) is a key circadian clock gene. Per2 mutant (Per2(m/m)) mice show an increase in lymphomas and deregul...

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Hauptverfasser: Wood, Patricia A., Yang, Xiaoming, Taber, Andrew, Oh, Eun-Young, Ansell, Christine, Ayers, Stacy E., Al-Assaad, Ziad, Carnevale, Kevin, Berger, Franklin G., Peña, Maria Marjorette O., Hrushesky, William J.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136553/
https://ncbi.nlm.nih.gov/pubmed/19010825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-08-0196
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