Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ~37% of human tumors have undergone a genome-doubling event during their development. This potentially oncogenic effect of tetraploidy is countered by a p53-dependent barrier to proliferation. However, the...

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Bibliographic Details
Main Authors: Ganem, Neil J., Cornils, Hauke, Chiu, Shang-Yi, O’Rourke, Kevin P., Arnaud, Jonathan, Yimlamai, Dean, Théry, Manuel, Camargo, Fernando D., Pellman, David
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136486/
https://ncbi.nlm.nih.gov/pubmed/25126788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.06.029
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