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Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation
Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ~37% of human tumors have undergone a genome-doubling event during their development. This potentially oncogenic effect of tetraploidy is countered by a p53-dependent barrier to proliferation. However, the...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136486/ https://ncbi.nlm.nih.gov/pubmed/25126788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.06.029 |
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