Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ~37% of human tumors have undergone a genome-doubling event during their development. This potentially oncogenic effect of tetraploidy is countered by a p53-dependent barrier to proliferation. However, the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Ganem, Neil J., Cornils, Hauke, Chiu, Shang-Yi, O’Rourke, Kevin P., Arnaud, Jonathan, Yimlamai, Dean, Théry, Manuel, Camargo, Fernando D., Pellman, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136486/
https://ncbi.nlm.nih.gov/pubmed/25126788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.06.029
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge