AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling

In neurons, Ca(2+) influx through L-type voltage-gated Ca(2+) channels (LTCC) couples electrical activity to changes in transcription. LTCC activity is elevated by the cAMP-dependent protein kinase (PKA) and depressed by the Ca(2+)-dependent phosphatase calcineurin (CaN), with both enzymes localized...

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Détails bibliographiques
Auteurs principaux: Murphy, Jonathan G., Sanderson, Jennifer L., Gorski, Jessica A., Scott, John D., Catterall, William A., Sather, William A., Dell’Acqua, Mark L.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136445/
https://ncbi.nlm.nih.gov/pubmed/24835999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.027
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