Genetic and molecular basis of drug resistance and species-specific drug action in Schistosome parasites

Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s. We crossed parental parasites differing ~500-fold in drug response, determined drug sensitivity and marker segregation in clonally-derived F2s, and identified a single QTL (LOD=31) on chromosome 6....

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Main Authors: Valentim, Claudia L. L., Cioli, Donato, Chevalier, Frédéric D., Cao, Xiaohang, Taylor, Alexander B., Holloway, Stephen P., Pica-Mattoccia, Livia, Guidi, Alessandra, Basso, Annalisa, Tsai, Isheng J., Berriman, Matthew, Carvalho-Queiroz, Claudia, Almeida, Marcio, Aguilar, Hector, Frantz, Doug E., Hart, P. John, LoVerde, Philip T., Anderson, Timothy J.C.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136436/
https://ncbi.nlm.nih.gov/pubmed/24263136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243106
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