CD40L-Adjuvanted DNA/Modified Vaccinia Virus Ankara Simian Immunodeficiency Virus SIV239 Vaccine Enhances SIV-Specific Humoral and Cellular Immunity and Improves Protection against a Heterologous SIVE660 Mucosal Challenge

It remains a challenge to develop a successful human immunodeficiency virus (HIV) vaccine that is capable of preventing infection. Here, we utilized the benefits of CD40L, a costimulatory molecule that can stimulate both dendritic cells (DCs) and B cells, as an adjuvant for our simian immunodeficien...

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Bibliographische Detailangaben
Hauptverfasser: Kwa, Suefen, Lai, Lilin, Gangadhara, Sailaja, Siddiqui, Mariam, Pillai, Vinod B., Labranche, Celia, Yu, Tianwei, Moss, Bernard, Montefiori, David C., Robinson, Harriet L., Kozlowski, Pamela A., Amara, Rama Rao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136340/
https://ncbi.nlm.nih.gov/pubmed/24920805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00975-14
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