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Structure of the Herpes Simplex Virus 1 Genome: Manipulation of Nicks and Gaps Can Abrogate Infectivity and Alter the Cellular DNA Damage Response

The herpes simplex virus 1 (HSV-1) virion DNA contains nicks and gaps, and in this study a novel assay for estimating the size and number of gaps in virion DNA was developed. Consistent with previous reports, we estimate that there are approximately 15 gaps per genome, and we calculate the average g...

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Библиографические подробности
Главные авторы: Smith, Samantha, Reuven, Nina, Mohni, Kareem N., Schumacher, April J., Weller, Sandra K.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136335/
https://ncbi.nlm.nih.gov/pubmed/24965466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01723-14
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