Murine Cytomegalovirus Virion-Associated Protein M45 Mediates Rapid NF-κB Activation after Infection

Murine cytomegalovirus (MCMV) rapidly induces activation of nuclear factor κB (NF-κB) upon infection of host cells. After a transient phase of activation, the MCMV M45 protein blocks all canonical NF-κB-activating pathways by inducing the degradation of the gamma subunit of the inhibitor of κB kinas...

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Bibliographic Details
Main Authors: Krause, Eva, de Graaf, Miranda, Fliss, Patricia M., Dölken, Lars, Brune, Wolfram
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136316/
https://ncbi.nlm.nih.gov/pubmed/24942588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00684-14
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