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Increased mutation frequency of feline immunodeficiency virus lacking functional deoxyuridine-triphosphatase.

Feline immunodeficiency virus (FIV) encodes the enzyme deoxyuridine-triphosphatase (DU; EC 3.6.1.23) between the coding regions for reverse transcriptase and integrase in the pol gene. Here, we report the in vivo infection of cats with a DU- variant of the PPR strain of FIV and compare its growth pr...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lerner, D L, Wagaman, P C, Phillips, T R, Prospero-Garcia, O, Henriksen, S J, Fox, H S, Bloom, F E, Elder, J H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41363/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7638216/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.16.7480
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