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Binding of the Kaposi's Sarcoma-Associated Herpesvirus to the Ephrin Binding Surface of the EphA2 Receptor and Its Inhibition by a Small Molecule

The ephrin receptor tyrosine kinase A2 (EphA2) is an entry receptor for Kaposi's sarcoma-associated herpesvirus (KSHV) that is engaged by the virus through its gH/gL glycoprotein complex. We describe here that natural ephrin ligands inhibit the gH/gL-EphA2 interaction. The effects of point muta...

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Bibliografske podrobnosti
Main Authors: Hahn, Alexander S., Desrosiers, Ronald C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136269/
https://ncbi.nlm.nih.gov/pubmed/24899181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01392-14
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