Disease Severity Is Associated with Differential Gene Expression at the Early and Late Phases of Infection in Nonhuman Primates Infected with Different H5N1 Highly Pathogenic Avian Influenza Viruses

Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans causes severe pneumonia with high mortality. To better understand the mechanisms via which H5N1 viruses induce severe disease in humans, we infected cynomolgus macaques with six different H5N1 strains isolated from h...

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Detalhes bibliográficos
Main Authors: Muramoto, Yukiko, Shoemaker, Jason E., Le, Mai Quynh, Itoh, Yasushi, Tamura, Daisuke, Sakai-Tagawa, Yuko, Imai, Hirotaka, Uraki, Ryuta, Takano, Ryo, Kawakami, Eiryo, Ito, Mutsumi, Okamoto, Kiyoko, Ishigaki, Hirohito, Mimuro, Hitomi, Sasakawa, Chihiro, Matsuoka, Yukiko, Noda, Takeshi, Fukuyama, Satoshi, Ogasawara, Kazumasa, Kitano, Hiroaki, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136255/
https://ncbi.nlm.nih.gov/pubmed/24899188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00907-14
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