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Zinc Finger Endonuclease Targeting PSIP1 Inhibits HIV-1 Integration

Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor (LEDGF) protein, might restrain an ea...

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Bibliografische gegevens
Hoofdauteurs: Badia, Roger, Pauls, Eduardo, Riveira-Munoz, Eva, Clotet, Bonaventura, Esté, José A., Ballana, Ester
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136077/
https://ncbi.nlm.nih.gov/pubmed/24820090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02690-14
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