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Zinc Finger Endonuclease Targeting PSIP1 Inhibits HIV-1 Integration

Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor (LEDGF) protein, might restrain an ea...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Badia, Roger, Pauls, Eduardo, Riveira-Munoz, Eva, Clotet, Bonaventura, Esté, José A., Ballana, Ester
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136077/
https://ncbi.nlm.nih.gov/pubmed/24820090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02690-14
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