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Zinc Finger Endonuclease Targeting PSIP1 Inhibits HIV-1 Integration
Genome editing using zinc finger nucleases (ZFNs) has been successfully applied to disrupt CCR5 or CXCR4 host factors and inhibit viral entry and infection. Gene therapy using ZFNs to modify the PSIP1 gene, which encodes the lens epithelium-derived growth factor (LEDGF) protein, might restrain an ea...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136077/ https://ncbi.nlm.nih.gov/pubmed/24820090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02690-14 |
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