Antimycobacterial Drugs Modulate Immunopathogenic Matrix Metalloproteinases in a Cellular Model of Pulmonary Tuberculosis

Tuberculosis is characterized by extensive destruction and remodelling of the pulmonary extracellular matrix. Stromal cell-derived matrix metalloproteinases (MMPs) are implicated in this process and may be a target for adjunctive immunotherapy. We hypothesized that MMPs are elevated in bronchoalveol...

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Autors principals: Singh, Shivani, Kubler, Andre, Singh, Utpal K., Singh, Ajay, Gardiner, Harriet, Prasad, Rajniti, Elkington, Paul T., Friedland, Jon S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
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Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136059/
https://ncbi.nlm.nih.gov/pubmed/24890593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02141-13
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