Emergence of Resistance to Atovaquone-Proguanil in Malaria Parasites: Insights from Computational Modeling and Clinical Case Reports

The usefulness of atovaquone-proguanil (AP) as an antimalarial treatment is compromised by the emergence of atovaquone resistance during therapy. However, the origin of the parasite mitochondrial DNA (mtDNA) mutation conferring atovaquone resistance remains elusive. Here, we report a patient-based s...

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Bibliographic Details
Main Authors: Cottrell, Gilles, Musset, Lise, Hubert, Véronique, Le Bras, Jacques, Clain, Jérôme
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136057/
https://ncbi.nlm.nih.gov/pubmed/24867967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02550-13
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