In Vitro and In Vivo Evidence for Amphotericin B as a P-Glycoprotein Substrate on the Blood-Brain Barrier

Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing...

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Détails bibliographiques
Auteurs principaux: Wu, Ji-Qin, Shao, Kun, Wang, Xuan, Wang, Rui-Ying, Cao, Ya-Hui, Yu, Yun-Qiu, Lou, Jin-Ning, Chen, Yan-Qiong, Zhao, Hua-Zhen, Zhang, Qiang-Qiang, Weng, Xin-Hua, Jiang, Chen, Zhu, Li-Ping
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136029/
https://ncbi.nlm.nih.gov/pubmed/24867970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02535-14
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