In Vitro and In Vivo Evidence for Amphotericin B as a P-Glycoprotein Substrate on the Blood-Brain Barrier

Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing...

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Detalhes bibliográficos
Main Authors: Wu, Ji-Qin, Shao, Kun, Wang, Xuan, Wang, Rui-Ying, Cao, Ya-Hui, Yu, Yun-Qiu, Lou, Jin-Ning, Chen, Yan-Qiong, Zhao, Hua-Zhen, Zhang, Qiang-Qiang, Weng, Xin-Hua, Jiang, Chen, Zhu, Li-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136029/
https://ncbi.nlm.nih.gov/pubmed/24867970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02535-14
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