In Vitro and In Vivo Evidence for Amphotericin B as a P-Glycoprotein Substrate on the Blood-Brain Barrier

Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing...

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Bibliografiset tiedot
Päätekijät: Wu, Ji-Qin, Shao, Kun, Wang, Xuan, Wang, Rui-Ying, Cao, Ya-Hui, Yu, Yun-Qiu, Lou, Jin-Ning, Chen, Yan-Qiong, Zhao, Hua-Zhen, Zhang, Qiang-Qiang, Weng, Xin-Hua, Jiang, Chen, Zhu, Li-Ping
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2014
Aiheet:
Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136029/
https://ncbi.nlm.nih.gov/pubmed/24867970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02535-14
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