Antitrypanosomal Activity of Fexinidazole Metabolites, Potential New Drug Candidates for Chagas Disease

This study was designed to verify the in vivo efficacy of sulfoxide and sulfone fexinidazole metabolites following oral administration in a murine model of Chagas disease. Female Swiss mice infected with the Y strain of Trypanosoma cruzi were treated orally once per day with each metabolite at doses...

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Bibliografiske detaljer
Main Authors: Bahia, Maria T., Nascimento, Alvaro F. S., Mazzeti, Ana Lia, Marques, Luiz F., Gonçalves, Karolina R., Mota, Ludmilla W. R., Diniz, Lívia de F., Caldas, Ivo S., Talvani, André, Shackleford, David M., Koltun, Maria, Saunders, Jessica, White, Karen L., Scandale, Ivan, Charman, Susan A., Chatelain, Eric
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136024/
https://ncbi.nlm.nih.gov/pubmed/24841257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02754-13
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