Antitrypanosomal Activity of Fexinidazole Metabolites, Potential New Drug Candidates for Chagas Disease

This study was designed to verify the in vivo efficacy of sulfoxide and sulfone fexinidazole metabolites following oral administration in a murine model of Chagas disease. Female Swiss mice infected with the Y strain of Trypanosoma cruzi were treated orally once per day with each metabolite at doses...

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Detalhes bibliográficos
Main Authors: Bahia, Maria T., Nascimento, Alvaro F. S., Mazzeti, Ana Lia, Marques, Luiz F., Gonçalves, Karolina R., Mota, Ludmilla W. R., Diniz, Lívia de F., Caldas, Ivo S., Talvani, André, Shackleford, David M., Koltun, Maria, Saunders, Jessica, White, Karen L., Scandale, Ivan, Charman, Susan A., Chatelain, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136024/
https://ncbi.nlm.nih.gov/pubmed/24841257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02754-13
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