Structural Analysis of Base Substitutions in Thermus thermophilus 16S rRNA Conferring Streptomycin Resistance

Streptomycin is a bactericidal antibiotic that induces translational errors. It binds to the 30S ribosomal subunit, interacting with ribosomal protein S12 and with 16S rRNA through contacts with the phosphodiester backbone. To explore the structural basis for streptomycin resistance, we determined t...

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Main Authors: Demirci, Hasan, Murphy, Frank V., Murphy, Eileen L., Connetti, Jacqueline L., Dahlberg, Albert E., Jogl, Gerwald, Gregory, Steven T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2014
Ábhair:
Mechanisms of Resistance
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136021/
https://ncbi.nlm.nih.gov/pubmed/24820088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02857-14
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