Structural Analysis of Base Substitutions in Thermus thermophilus 16S rRNA Conferring Streptomycin Resistance

Streptomycin is a bactericidal antibiotic that induces translational errors. It binds to the 30S ribosomal subunit, interacting with ribosomal protein S12 and with 16S rRNA through contacts with the phosphodiester backbone. To explore the structural basis for streptomycin resistance, we determined t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Demirci, Hasan, Murphy, Frank V., Murphy, Eileen L., Connetti, Jacqueline L., Dahlberg, Albert E., Jogl, Gerwald, Gregory, Steven T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2014
Gaiak:
Mechanisms of Resistance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136021/
https://ncbi.nlm.nih.gov/pubmed/24820088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02857-14
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