Studies on the Antileishmanial Mechanism of Action of the Arylimidamide DB766: Azole Interactions and Role of CYP5122A1

Arylimidamides (AIAs) are inspired by diamidine antimicrobials but show superior activity against intracellular parasites. The AIA DB766 {2,5-bis[2-(2-i-propoxy)-4-(2-pyridylimino)aminophenyl]furan hydrochloride} displays outstanding potency against intracellular Leishmania parasites and is effectiv...

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Bibliographische Detailangaben
Hauptverfasser: Pandharkar, Trupti, Zhu, Xiaohua, Mathur, Radhika, Jiang, Jinmai, Schmittgen, Thomas D., Shaha, Chandrima, Werbovetz, Karl A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2014
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135980/
https://ncbi.nlm.nih.gov/pubmed/24890590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02405-14
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