Deletion of the Uracil Permease Gene Confers Cross-Resistance to 5-Fluorouracil and Azoles in Candida lusitaniae and Highlights Antagonistic Interaction between Fluorinated Nucleotides and Fluconazole

We characterized two additional membrane transporters (Fur4p and Dal4p) of the nucleobase cation symporter 1 (NCS1) family involved in the uptake transport of pyrimidines and related molecules in the opportunistic pathogenic yeast Candida lusitaniae. Simple and multiple null mutants were constructed...

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Detalhes bibliográficos
Main Authors: Gabriel, Frédéric, Sabra, Ayman, El-Kirat-Chatel, Sofiane, Pujol, Sophie, Fitton-Ouhabi, Valérie, Brèthes, Daniel, Dementhon, Karine, Accoceberry, Isabelle, Noël, Thierry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135975/
https://ncbi.nlm.nih.gov/pubmed/24867971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00009-14
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