Flucytosine-Fluconazole Cross-Resistance in Purine-Cytosine Permease-Deficient Candida lusitaniae Clinical Isolates: Indirect Evidence of a Fluconazole Uptake Transporter

An unusual interaction between flucytosine and fluconazole was observed when a collection of 60 Candida lusitaniae clinical isolates was screened for cross-resistance. Among eight isolates resistant to flucytosine (MIC ≥ 128 μg/ml) and susceptible to fluconazole (0.5 < MIC < 2 μg/ml), four bec...

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Autori principali: Noël, Thierry, François, Fabienne, Paumard, Patrick, Chastin, Christiane, Brèthes, Daniel, Villard, Jean
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC152504/
https://ncbi.nlm.nih.gov/pubmed/12654658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.4.1275-1284.2003
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